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Recent Publications

 
  • Pillai DR, Lau R, Khairnar K, Lepore R, Via A, Staines HM, Krishna S.
    Artemether resistance in vitro is linked to mutations in PfATP6 that also interact with mutations in PfMDR1 in travellers returning with Plasmodium falciparum infections.Malar J. 2012 Apr 27;11(1):131.
  • Kremsner PG, Taylor T, Issifou S, Kombila M, Chimalizeni Y, Kawaza K, Akotet KB, Duscha M, Mordmüller B, Kösters K, Humberg A, Miller RS, Weina P, Duparc S, Möhrle J, Kun JFJ, Planche T, Teja-Isavadharm P, Simpson JA, Köhler C, Krishna S. (2011). A simplified intravenous artesunate regimen for severe malaria. Journal of Infectious Diseases 205:
  • Salcedo-Sora JE, Ochong E, Beveridge S, Johnson D, Nzila A, Biagini GA, Stocks PA, O'Neill PM, Krishna S, Bray PG, Ward SA. J Biol Chem. The molecular basis of folate salvage in Plasmodium falciparum: characterization of two folate transporters. 2011 Dec 30;286(52):44659-68. Epub 2011 Oct 13. PMID: 21998306 [PubMed - indexed for MEDLINE]
  • Cox-Singh J. Singh B, Daneshvar C, Planche T, Parker-Williams J, Krishna S. (2011). Antiinflammatory markers predominate in acute human Plasmodium knowlesi malaria. PLoS One 6:e20541.
  • Salcedo-Sora JE, Ochung E, Nzila A, Beveridge S, Biagini GA, Stocks PA, Johnson D, O’Neill PM, Krishna S, Ward SA, Bray PG. (2011). The molecular basis of folate salvage in Plasmodium falciparum: characterisation of two folate transporters. Journal of Biological Chemistry 286: 44659 – 44668.
  • 64Slavic K, Derbyshire E, Staines HM, Krishna S. (2011). Hexose transporters as novel targets for antiparasitic drug discovery. Malaria Journal 10: 165.
  • Slavic K, Talman AM, Delves MJ, Prudêncio M, Straschil U, Derbyshire ET, Xu Z, Sinden RE, Mota MM, Morin C, Tewari R, Krishna S, Staines HM. (2011). Use of a selective inhibitor to define the physiological importance of the plasmodial hexose transporter in the different stages of the parasite’s life cycle. Antimicrobial Agents and Chemotherapy 55: 2824-2830.
  • Lubell Y, Staedke S, Greenwood BM, Kamya M, Newton P, Molyneux M, Reyburn H, Snow R, D’Allesandro U, English M, Day N, Kremsner PG, Dondorp A, Mbacham W, Dorsey G, Owusu-Agyei S, Maitland K, Krishna S, Newton C, Pasvol G, von Seidlein L, Taylor T, White NJ, Binka F, Mills A, Whitty CJM. (2011). Likely health outcomes for untreated febrile illness in the tropics in decision and economic models; a Delphi survey PLoS One 6: e17439.
  • Pooley S, Fatih F, Krishna S, Gerisch M, Haynes RK, Wong H-N, Staines HM. (2011). Artemisone uptake in Plasmodium falciparum-infected erythrocytes. Antimicrobial Agents and Chemotherapy 55: 550-6 
  • Planche T,Macallan DC, Sobande T, Borrmann S, Kun JF, Krishna S, Kremsner PG. (2010). Nitric oxide generation in children with malaria and the NOS2G-954C promotor polymorphism. American Journal of Physiology, Regulatory, Integrative and Compatative Physiology 299: R1248-53 
  • Staines H, Derbyshire ET, Slavic K, Tattersall A, Vial V, Krishna S. (2010). Exploiting the therapeutic potential of transporters of Plasmodium falciparum. Trends in Parasitology 26: 284-96.
  • Cox-Singh J, Hiu J, Lucas S, Divis PC, Zulkarnaen AN, Wang PC, Adem P, Zaki SR, Singh B, Krishna S. (2010). Severe malaria: A case of fatal Plasmodium knowlesi infection with post mortem findings – a case report. Malaria Journal 9: 10 (http://www.malariajournal.com/content/9/1/10).
  • Staines H, Derbyshire ET, Slavic K, Tattersall A, Vial V, Krishna S. (2010). Exploiting the therapeutic potential of transporters of Plasmodium falciparum.Trends Parasitol. 2010 Jun;26(6):284-96. Epub 2010 Apr 12.
  • Krishna S, Pulcini S, Fatih F, Staines H.Artemisinins and the biological basis for the PfATP6/SERCA hypothesis.Trends Parasitol. 2010 Nov;26(11):517-23. Epub 2010 Jul 17.PMID: 20638904 [PubMed - indexed for MEDLINE]
  • Planche T, Macallan DC, Sobande T, Borrmann S, Kun JF, Krishna S, Kremsner PG.Nitric oxide generation in children with malaria and the NOS2G-954C promoter polymorphism.Am J Physiol Regul Integr Comp Physiol. 2010 Nov;299(5):R1248-53. Epub 2010 Sep 1.PMID: 20811009 [PubMed - indexed for MEDLINE]
  • Cowan ML, Rahman TM, Krishna S.Proteomic approaches in the search for biomarkers of liver fibrosis.Trends Mol Med. 2010 Apr;16(4):171-83. Epub 2010 Mar 19. Review.PMID: 20304704 [PubMed - indexed for MEDLINE]
  • Slavic K, Straschil U, Reininger L, Doerig C, Morin C, Teware R, Krishna S. (2010). Life cycle studies of the hexose transporter of Plasmodium species. Molecular Microbiology, 2010 Mar;75(6):1402-13. Epub 2009 Feb 1.
  • http://www.comed-project.org/index.php?id=18
  • Arnold A, Pope C, Bray S, Riley P, Breathnach A, Krishna S, Planche T. (2010). Prospective assessment of two-stage testing for Clostridium difficile. J Hosp Infect. 2010 Sep;76(1):18-22.
  • Krishna S, Pulcini S, Fatih F, Staines H. (2010). Artemisinins and the biological basis of the PfATP6/SERCA hypothesis. Trends Parasitol. 2010 Nov;26(11):517-23. Epub 2010 Jul 17.
  • Cowan M, Rahman T, Krishna S. (2010). Proteomic approaches in the search for biomarkers of liver fibrosis. Trends Mol Med. 2010 Apr;16(4):171-83. Epub 2010 Mar 19.
  • Gravett AM, Liu WM, Krishna S, Chan W-C, Haynes RK, Wilson N, Dalgleish AG. (2010). In vitro study of the anti-cancer effects of artemisone alone or in combination with other chemotherapeutic agents.Cancer Chemother Pharmacol. 2010 May 19. [Epub ahead of print]
  • Cardi D, Pozza A, Arnou B, Marchal E, Clausen JD, Andersen JP, Krishna S, Møller JV, le Maire M, Jaxel C. (2010). Purified E255L mutant Serca1a and purified PfATP6 are sensitive to SERCA-type inhibitors but insensitive to artemisinins. J Biol Chem. 2010 Aug 20;285(34):26406-16. Epub 2010 Jun 8.
  • Valderramos SG, Scanfield D, Uhlemann A-C, Fidock DA, Krishna S. (2010). Investigations into the role of the Plasmodium falciparum SERCA (PfATP6) L263E mutation in artemisinin action and resistance. Antimicrob Agents Chemother. 2010 Sep;54(9):3842-52. Epub 2010 Jun 21.
  • Cox-Singh J, Hiu J, Lucas SB, Divis PC, Zulkarnaen M, Chandran P, Wong KT, Adem P, Zaki SR, Singh B, Krishna S. (2010). Plasmodium knowlesi – the fifth human malaria. Chapter 13 in Emerging Infections 9 261-271. Scheld WM, Grayson ML, Hughes JM (Eds). Malar J. 2010 Jan 11;9:10.
  • Krishna S and Stich A. (2011). African Trypanosomiasis in Hunter’s Textbook of Tropical Medicine.
  • Kremsner PG, Valim C, Missinou M, Olola C, Krishna S, Issifou S, Kombila M, Bwanaisa L, Mithwanin S, Newton C, Agbenyega T, Pinder M, Bojang K, Wypij D, Taylor T. (2009). The prognostic value of circulating pigmented cells in severe malaria in African children. Journal of Infectious Diseases 199 142-50.
  • Gomes MF, Faiz MA, Gyapong J, Warasme M, Agbenyega T, Babiker A, Baiden F, Bin Yunus E, Binka F, Ckerk C, Folb P, Hassan R, Hossein Md A, Kimbute O, Kitua A, Krishna S, Makasi C, Mensah N, Mrango Z, Olliaro P, Peto R, Peto TJ, Rahman MR, Ribiero I, Samad R, White NJ for the Study 13 research group. (2009). Pre-referral rectal artesunate to prevent death and disability in severe malaria: placebo-controlled trial. The Lancet 373: 557-66.
  • Macallan DC, Abaye DA, Dottin S, Onanga M, Kombila M, Dzeing-Ella A, Kremsner PG, Krishna S, Planche T. (2009). Blood volume and red cell mass in children with moderate and severe malaria measured by chromium-53 dilution and gas chromatography/mass spectrometric analysis. Rapid Communications in Mass Spectrometry 23: 2467-75.
  • Prudêncio M, Derbyshire ET, Marques CA, Krishna S, Mota MM, Staines HM. (2009). Plasmodium berghei infection induces volume-regulated anion channel-like activity in human hepatoma cells. Cellular Microbiology 11: 1492-501.
  • Slavic K, Derbyshire E, Naftalin RJ, Krishna S, Staines HM. (2009). Comparison of effects of green tea catechins on apicomplexan hexose transporters and mammalian orthologues. Molecular and Biochemical Parasitology 168: 113-6.
  • Doerig C, Baker D, Billker O, Blackman MJ, Chitnis C, Dhar K, Heussler V, Holder AA, Kocken C, Krishna S, Langsley G, Lasonder E, Menard R, Meissner M, Pradel G, Ranford-Cartwright L, Sharma A, Sharma P, Tardieux T, Tatu U, Alano P. (2009). Signalling in malaria parasites. The MALSIG consortium. Parasite 16: 169-182.
  • Kremsner PG, Valim C, Missinou M, Olola C, Krishna S, Issifou S, Kombila M, Bwanaisa L, Mithwanin S, Newton C, Agbenyega T, Pinder M, Bojang K, Wypij D, Taylor T. (2009) The prognostic value of circulating pigmented cells in severe malaria in African children. Journal of Infectious Diseases, 199 (1) 142 - 150.
  • Gomes MF, Faiz MA, Gyapong J, Warasme M, Agbenyega T, Babiker A, Baiden F, Bin Yunus E, Binka F, Ckerk C, Folb P, Hassan R, Hossein Md A, Kimbute O, Kitua A, Krishna S, Makasi C, mensah N, Mrango Z, Olliaro P, Peto R, Peto TJ, Rahman MR, Ribiero I, Samad R, White NJ for the Study 13 research group. (2008). Pre-referral rectal artesunate to prevent death and disability in severe malaria: placebo-controlled trial. Lancet , E pub 2008, Dec 5.
  • Planche T, Aghaizu A, Holliman R, Polienicki J, Breathack A, Krishna S. (2008). Diagnosis of Clostridium difficile by use of toxin detection kits: a systematic review. Lancet Infectious Diseases , 8 (12), 777-84.
  • This paper has excited press interest:
  • http://www.ananova.com/news/story/sm_3069796.html
  • http://www.metro.co.uk/news/article.html?C_diff_cases_missed_by_testing&in_article_id=382593&in_page
  • http://news.uk.msn.com/Article.aspx?cp-documentid=10570729
  • http://news.bbc.co.uk/go/newsFeedXML/moreover/-/1/hi/health/7702814.stm
  • http://www.stgeorges.nhs.uk/press140.asp
  • http://www.newssniffer.co.uk/articles/169281/diff/0/1
  • http://www.express.co.uk/posts/view/68930/C-diff-cases-missed-by-testing
  • http://spoonfeedin.blogspot.com/2008/11/health-c-diff-testing-is-often-wrong.html
  • http://www.themedguru.com/articles/c_diff_tests_might_be_misleading_report_suggsts-86116062.html
  • http://groups.google.com/group/misc.health.alternative/browse_thread/thread/fd4bcc6f86597bd0/11000471748563ee?lnk=raot
  • http://www.theherald.co.uk/news/health/display.var.2464897.0.Research_casts_doubt_on_the_way_NHS_tests_for_C_Diff.php
  • Rojas-Galeano S, Hseih E, Agranoff D, Krishna S, Fernandez-Reyes D. (2008). Estimation of relevant variables on high-dimensional biological patterns using iterated weighted kernal functions. PLoS One, 26 : 3. http://www.plosone.org/article/info:doi/10.1371/journal.pone.0001806
  • Derbyshire E, Franssen FJ, de Vries E, Morin C, Woodrow CJ, Krishna S, Staines HM. (2008). Identification, expression and characterisation of a Babesia bovis hexose transporter. Molecular and Biochemical Parasitology, 161 (2):124-9.
  • Toovey S, Bustamante LY, Uhlemann A-C, East M, Krishna S. (2008). Effect of artemisinins and amino alcohol partner antimalarials on mammalian sarcoendoplasmic reticulum adenosine triphosphatase (SERCA) activity. Basic and Clinical Pharmacology and Toxicology, 103 (3):209-13.
  • Krishna S, Bustamante L, Haynes RK, Staines HM. (2008). Artemisinins: their growing importance in medicine. Trends in Pharmacological Sciences , 29 (10), 520 -7.
  • Invited review
  • Patel AP, Staines HM, Krishna S. (2008). New antimalarial targets: the example of glucose transport. Travel Medicine and Infectious Diseases 6 : 58-66.
  • Nair S, Nash N, Sudimack D, Singlam S, Barends M, Uhlemann A-C, Krishna S, Nosten F, Anderson TJC. (2007). Recurrent gene amplification and soft selective sweeps during evolution of multidrug resistance in malaria. Molecular Biology and Evolution, 24 :562-573.
  • Uhlemann A-C, Brockman A, McGready R, Nair S, Ashley E, Singhasivanon P, Anderson TJC, Krishna S, White NJ, Nosten F, Price RN. Intrahost selection of Plasmodium falciparum pfmdr1 alleles following antimalarial treatment on the western border of Thailand. (2007). Journal of Infectious Diseases , 195 : 134 -141.
  • Sisowath C, Ferreira PE, Bustamante LY, Dahlström S, Mårtensson A, Björkman A, Krishna S, Gil JP. (2007). The role of pfmdr1 in Plasmodium falciparum tolerance to artemether-lumefantrine in Africa. Tropical Medicine and International Health, 12 : 736-742.
  • Uhlemann A-C, Wittlin S, Matile H, Bustamante LY, Krishna S. (2007). Studies on the mechanism of antimalarial action of synthetic trioxolane OZ277. Antimicrobial Agents and Chemotherapy , 51 : 667-72.
  • Ionita M, Krishna S, Léo P-M, Morin C, Patel AP. (2007). Interaction of O -(undec-10-en)-yl-D-glucose derivatives with the Plasmodium falciparum hexose transporter (PfHT). Bioorganic and Medicinal Chemistry, 17 : 4934-7.
  • Mishina YV, Krishna S, Haynes RK, Meade JC. (2007). Artemisinins inhibit Trypanosoma cruzi and Trypanosoma brucei rhodesiense in vitro growth and SERCA pump activity. Antimicrobial Agents and Chemotherapy , 51 (5):1852-4.
  • Price L, Raynor C, Krishna S, Planche T. (2007). ARDS in Plasmodium vivax malaria: case report and review of the literature. Transactions of the Royal Society of Tropical Medicine and Hygiene. 101 : 655-659.
  • Haynes RK, Chan WC, Lung C-M, Uhlemann A-C, Eckstein U, Taramelli D, Parapini S, Monti D, Krishna S. (2007). The Fe 2+ -mediated decomposition, PfATP6-binding and antimalarial activities of artemisone and other artemisinins: the unlikelihood of C-centred radicals as bioactive intermediates. ChemMedChem 2 : 1480-1497.
  • Issifou S, Kendjo E, Missinou MA, Matsiegui PB, Dzeing-Ella A, Dissanami FA, Kombila M, Krishna S, Kremsner PG. (2007). Differences in presentation of severe malaria in urban and rural Gabon. American Journal of Tropical Medicine and Hygiene 77 : 1015-1019.
  • Invited reviews
  • Ramharter M, Adegnika AA, Agnandji ST, Matsiegui PB, Grobusch MP, Winkler S, Graninger W, Krishna S, Yazdanbakhsh M, Mordmüller B, Lell B, Missinou MA, Mavoungou E, Issifou S, Kremsner PD. (2007). History and perspectives of medical research at the Albert Schweitzer Hospital in Lambaréné, Gabon. Wiener Klinische Wochenschrift 119 (Suppl 3) : 8-12.
  • Yamey G on Behalf of the Interviewees (2007). Which single intervention would do the most to improve the health of those living on less than $1 per day? PLoS Medicine 4 : 1557-1560.
  • Taylor TE, Olola C, Valim C, Agbenyega T, Kremsner P, Krishna S, Kwiatkowski D, Newton C, Missinou M, Pinder M, Wypij D on behalf of the SMAC network. (2006). Standardised data collection for multi-center clinical studies of severe malaria in African children: establishing the SMAC network Transactions of the Royal Society of Tropical Medicine and Hygiene, 100 : 615-622.
  • Fayolle M, Ionita M, Krishna S, Morin C, Patel A. (2006). Probing structure/affinity relationships for the Plasmodium falciparum hexose transporter (PfHT). Bioorganic and Medicinal Chemistry, 16 : 1267-1271.
  • Price RN, Uhlemann A-C, van Vugt, M, Brockman, A, Nair S, Hutatalung R, Nash D, Phaipun L, Anderson TJC, Krishna S White NJ, Nosten F. (2006). Molecular and pharmacological determinants of therapeutic response to artemether-lumefantrine in multi-drug resistant Plasmodium falciparum malaria Clinical Infectious Diseases, 42 :1570-1577.
  • Jarvis JN, Planche T, Bicanic T, Dzeing A, Kombila M, Borrmann S, Kremsner PG, Krishna S. (2006). Lactic acidosis in Gabonese children with severe malaria is unrelated to dehydration. Clinical Infectious Diseases, 42 ; 1719-25
  • Kreidenweiss A, Mordmüller B, Krishna S, Kremsner PG (2006). Antimalarial activity of a synthetic endoperoxide (RBx-11160/OZ277) in Gabonese Plasmodium falciparum isolates. Antimicrobial Agents and Chemotherapy 50: 1535-1537.
  • Krishna S, Woodrow CJ, Staines H, Haynes R, Mercereau-Puijalon O. (2006). Re-evaluation of how artemisinins work in the light of emerging evidence for in vitro resistance. Trends in Molecular Medicine, 12 : 200-205.
  • Agranoff D, Fernandez-Reyes D, Papadopoulos M, Rojas SA, Herbster M, Loosemore A, Tarelli E, Sheldon J, Schwenk A, Pollok R, Rayner C and Krishna S. (2006). Diagnosis of tuberculosis by serum proteomic fingerprinting. The Lancet, 368 : 1012-1021.See also Editorial comment in that issue.
  • This paper has excited press interest:
  • http://news.bbc.co.uk/1/hi/health/5341968.stm
  • http://www.physorg.com/news77423174.html
  • http://www.channelnewsasia.com/stories/health/view/230363/1/.html
  • http://www.newscientist.com/article/dn10074-new-test-offers-hope-for-swift-tb-diagnosis.html
  • http://news.yahoo.com/s/afp/20060913/hl_afp/healthtuberculosistest_060913230643
  • http://www.scidev.net/news/index.cfm?fuseaction=readnews&itemid=3097&language=1
  • http://www.channelnewsasia.com/stories/health/view/230363/1/.html
  • See also:
  • http://www.mrc.ac.uk/index/public-interest/public-news_centre/public-press_office/public-press_2006/public-press_14_sept_06.html
  • Sidhu ABS, Uhlemann A-C, Valderramos SG, Valderramos J-C, Krishna S, Fidock DA. (2006). Decreasing pfmdr1 copy number in Plasmodium falciparum heightens sensitivity to mefloquine, lumefantrine, halofantrine, quinine and artemisinin. Journal of Infectious Diseases, 194 : 528-535.
  • Simpson JA, Agbenyega T, Barnes KI, Perri GD, Folb P, Gomes M, Krishna S , Krudsood S, Looareesuwan S, Mansor S, McIlleron H, Miller R, Molyneux M, Mwenechanya J, Navaratnam V, Nosten F, Olliaro P, Pang L, Ribeiro I, Tembo M, van Vugt M, Ward S, Weerasuriya K, Win K, White NJ. (2006) Population pharmacokinetic analysis of rectal artesunate in patients with malaria. PLoS Medicine, 3 2113-2123.
  • Vera J, Hensiek A, Woodrow CJ, Crawley F, Krishna S. (2006). Ophthalmoplegia and slurred speech in an intravenous drug user. PLoS Medicine, 3 : 2209-2211.
  • Jeffares, DC, Pain A, Berry A, Cox AJ, Stalker J, Ingle CE, Quail MA, Kyes S, Siebenthall K, Uhlemann A-C, Krishna S, Newbold C, Dermitzakis ET, Berriman M. (2006). Genome variation and evolution of the malaria parasite Plasmodium falciparum . Nature Genetics. 39 : 120-5.
  • Burkhardt D, Wiesner J, Stoesser N, Ramharter M, Uhlemann A-C, Issifou S, Jomaa H, Krishna S, Kremsner PG, Borrmann S. (2006). Delayed parasite elimination in human infections treated with clindamycin parallels the “delayed death” of Plasmodium falciparum in vitro. International Journal of Parasitology , 37 (7):777-85.
  • Invited reviews
  • Planche T and Krishna S. (2006). Severe malaria; metabolic complications. Current Molecular Medicine, 6 : 141-153.
  • Woodrow CJ and Krishna S. (2006). Antimalarial drugs: recent advances in molecular determinants of resistance and their clinical significance. Cell and Molecular Life Sciences 14 : 1586-96.
  • Editorial
  • Drug development papers in PLoS Medicine : how we try to spot a winner. (2006). 3 : 2169 – 2170.
  • Dzeing-Ella A, Nze Obiang PC, Tchoua R, Planche T, Mboza B. Mbounja M, Jarvis J, Kendjo E, Kremsner P.G, Krishna S, Kombila M. (2005). Severe falciparum malaria in Gabonese children: clinical and laboratory features. Malaria Journal, 4 :1.
  • Agranoff D, Collins L, Kehres D, Harrison T, Maguire M, Krishna S. (2005). The Nramp orthologue of Cryptococcus neoformans is a pH-dependent transporter of manganese, iron, cobalt and nickel. Biochemical Journal, 385 : 225-232.
  • Agranoff D, Stich A, Abel P, Krishna S. (2005). Proteomic fingerprinting for the diagnosis of human African trypanosomiasis. Trends in Parasitology, 21 : 154-157.
  • Stewart ML, Krishna S, Burchmore RJS, Brun R, De Koning HP, Boykin DW, Tidwell RR, Barrett MP. (2005). Detection of arsenical drug resistance in Trypanosoma brucei using a simple fluorescence test. The Lancet, 366 : 486-487. See also Editorial in The Lancet .
  • Ramharter M, Oyakhirome S, Klouwenberg PK, Adégnika AA, Agnandji ST, Missinou M, Matsiégui P-B, Mordmüller B, Borrmann S, Kun JF, Lell B, Krishna S, Graninger W,, Issifou S, Kremsner PG. (2005). Artesunte-clindamycin versus quinine-clindamycin in the treatment of Plasmodium falciparum malaria: a randomised controlled trial. Clinical Infectious Diseases 40: 1777-1784.
  • Uhlemann A-C, Cameron A, Eckstein-Ludwig U, Fischbarg J, Iserovich P, Zuniga FA, East M, Lee A, Brady L, Haynes RK, Krishna S. (2005). A single amino acid can determine sensitivity of SERCAs to artemisinins. Nature Structural and Molecular Biology, 12 : 628-9.
  • This paper generated considerable publicity including the following:
  • http://www.scidev.net/content/news/eng/malaria-parasite-could-develop-resistance-to-key-drug.cfm
  • BioWorld International article,
  • http://hum-molgen.org/NewsGen/06-2005/msg18.html
  • http://news.bbc.co.uk/2/hi/health/4615023.stm
  • Uhlemann A-C, Ramharter M, Lell B, Kremsner PG, Krishna S. (2005). Amplification of Plasmodium falciparum multi-drug resistant gene 1 ( pfmdr1 ) in isolates from Gabon. Journal of Infectious Diseases, 192 : 1830-5.
  • Newton CRJC, Valim C, Krishna S, Wypij D, Olola C. Agbenyega T, Taylor T and the SMAC network (2005). The predictive value of measures of acid/base balance in pediatric falciparum malaria compared to other clinical and laboratory parameters. Clinical Infectious Diseases, 41 : 948-957.
  • Book
  • Sullivan D & Krishna S. (2005) (Eds.). Malaria: Drugs, disease and post-genomic biology. Current Topics in Microbiology and Immunology 295. Springer-Verlag (Berlin Heidelberg). 438 pages (16 chapters). ISBN 3-540-25363-7.
  • Invited reviews
  • Edwards G & Krishna S (2005). Pharmacokinetic and pharmacodynamic issues in the treatment of infectious disease: antiparasitic agents. European Journal of Clinical Microbiology and Infectious Diseases (2004) x ; 1-10.
  • Woodrow CJ, Haynes RK and Krishna S. (2005). Artemisinins: Postgraduate Medical Journal, 81 : 71-78.
  • Krishna S (2005). The Cinchona Alkaloids: Pharmacokinetic and pharmacodynamic issues in the treatment of parasitic infections. In “ Antimicrobial Therapy and Vaccines ” Volume II Antimicrobial agents (Eds Yu V, Edwards G. McKinnon PS, Peloquin C, Morse GD) 2 nd . ed. Williams and Wilkins p 949-959.
  • Edwards G and Krishna S (2005). The Cinchona Alkaloids: Quinine and quinidine. In “ Antimicrobial Therapy and Vaccines ” Volume II Antimicrobial agents (Eds Yu V, Edwards G. McKinnon PS, Peloquin C, Morse GD) 2 nd . ed. Williams and Wilkins p 1167-1197.
  • Woodrow CJ and Krishna S. (2005). Molecular approaches to malaria: glycolysis in asexual stage parasites. In “ Malaria, parasite biology, pathogenesis and protection ”. Ed Sherman IW. American Society of Microbiology .
  • Krishna S and Stich A. (2005). The trypanosomiases: African and American. Medicine, 33 :8 50 - 53.
  • Planche T and Krishna S. (2005). The relevance of malaria pathophysiology to strategies of clinical management. Current Opinion in Infectious Disease, 18 : 369-375.
  • Abel P, Godi K, Loa V, Behrend M, Musolf J, Fleischmann H, Théophile J, Krishna S, Stich A. (2004). Retaking control of sleeping sickness in Angola. Tropical Medicine and International Health , 9 : 141-148.
  • International Artemisinin Study Group: Adjuik M, Agnamey P, Babiker A, Baptista J, Borrmann S, Brasseur P, Carnevale P, Cisse M, Collins R, D'Alessandro U, Day N, de Boom W, Doherty T, Garner P, Gikunda S, Gil V, Greenwood B, Guthmann JP, Henry MC, Kremsner PG, Konaté E, Krishna S, Lalloo D, Lange P, Loolpapit M, Malenga G, Marquino W, Marsh K, Milligan P, Molyneux M, Mugittu K, Niangue J, Nosten F, Ntoumi F, Obonyo C, Ochieng F, Olliaro P, Oloo AJ, Osorio L, Pinoges L, Priotto G, Ruebush T, Simpson J, Sirima SB, Some E, Taylor B, ter Kuile F, Tiono A, von Seidlein L, Watkins B, White N. Artesunate combinations for treatment of malaria. (2004). The Lancet, 363 : 9-17.
  • Lawn S, Krishna S, Jarvis J, Joët T, Macallan D. (2004). Pernicious complications of benign tertian malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene, 97 : 551-553.
  • Papadopoulos MC, Abel P, Agranoff D, Stich A, Loosemore A, Planche T, Bell BA, Wilkins P, Tarelli E and Krishna S. (2004). A novel and highly accurate diagnostic test for human African trypanosomiasis. The Lancet, 363 : 1358-1363.
  • This paper generated media interest:
  • http://news.bbc.co.uk/1/hi/health/3651033.stm
  • http://www.scienceblog.com/community/older/2004/5/20044853.shtml
  • http://www.innovations-report.de/html/berichte/medizin_gesundheit/bericht-28315.html
  • Kremsner PG & Krishna S. (2004). Antimalarial combinations. The Lancet, 364 : 285-294.
  • Price RN, Uhlemann A-C, Brockman A, McGready R, Ashley E, Phaipun L, Patel R, Laing K. Looareesuwan S, White N.J, Nosten F, Krishna S. (2004). Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy number. The Lancet, 364 : 438-447.
  • Planche T, Onanga M, Schwenk A, Dzeing A, Borrman S, Faucher J-F , Ngou-Milama E , Bluck L , Ward L, Kombila M, Kremsner PG, Krishna S. (2004). Assessment of volume depletion in children with malaria. PLoS Medicine, 1 :56-63.
  • Jo ë t T, Chotivanich K, Silamut K, Morin C, Patel AP, Krishna S. (2004). Analysis of the Plasmodium vivax hexose transporter and characterization of a parasitocidal inhibitor. Biochemical Journal, 381 : 905-909.
  • Borrmann S, Oyakhirome S, Esser G, Issifou S, Grobusch MP, Krishna S, Kremsner PG. (2004). Evaluation of a simple and inexpensive photometric device for the measurement of hemoglobin. American Journal of Tropical Medicine and Hygiene , 71 : 691-692.
  • Saliba KJ, Krishna S, Kirk K. (2004). Inhibition of hexose transport and abrogation of pH homeostasis in the intraerythrocytic malaria parasite by an O -3-hexose derivative. FEBS letter, 570 : 93-96.
  • Papadopoulos MC, Manley GT, Krishna S, Verkman AS. (2004). Aquaporin 4 facilitates reabsorption of excess fluid in vasogenic brain edema. FASEB Journal, 18 : 1291-3.
  • Invited reviews
  • Medicines for Malaria Annual Report 2003. Krishna S. (2004). Developments in antimalarial treatment. 8-9.
  • Papadopoulos MC, Saadoun S, Binder DK, Manley GT, Krishna S, Verkman AS. (2004). Molecular mechanisms of brain tumor edema. Neuroscience , 129 : 1009-1018.
  • Krishna S, Uhlemann A-C, Haynes RK. (2004). Artemisinins: Mechanisms of action and potential for resistance. Drug Resistance Updates, 7 :233-44.
  • Haynes RK and Krishna S. (2004). Artemisinins: activities and actions. Microbes and Infection, 6 :1339-46.
  • Agranoff D and Krishna S. (2004). Metal ion transport and regulations in Mycobacterium tuberculosis . Frontiers in Bioscience, 9 : 2996-3006.
  • Joët T and S. Krishna. (2004). The hexose transporter of Plasmodium falciparum is a worthy drug target. Acta Tropica, 89 : 371-374.
  • Borrmann S, Adegnika AA, Missinou MA, Binder RK, Issifou S, Schindler A, Matsiegui P-B, Kun JFJ, Krishna S, Lell B, Kremsner PG. (2003). Short Course of Artesunate for the Treatment of Uncomplicated Plasmodium falciparum Malaria in Gabon Antimicrobial Agents and Chemotherapy, 47 : 901-904.
  • Agbenyega T, Planche T, Bedu-Addo A, Ansong D, Owusu-Ofori A, Bhattaram VA, Nagaraja NV, Shroads AL, Henderson GN, Hutson AD, Derendorf H, Krishna S, Stacpoole P. (2003). Population kinetics, efficacy and safety of dichloroacetate for lactic acidosis due to severe malaria Journal of Clinical Pharmacology, 43 : 386-396.
  • Jo ë t T, Eckstein-Ludwig U, Morin C, Krishna S. The hexose transporter of Plasmodium falciparum is a novel drug target (2003). Proceedings of the National Academy of Sciences (USA), 100 : 7476-9.
  • Stich A, Barrett M, Krishna S. (2003). Waking up to Sleeping Sickness. Parasitology Today, 19 : 195-197.
  • Eckstein-Ludwig U, Webb RJ, van Goethem IDA, East JM, Lee AG, Kimura M, O'Niell PM, Bray P, Ward S, Krishna S. (2003). Artemisinins target the SERCA of Plasmodium falciparum . Nature, 424 : 957-961.
  • This work generated considerable interest. See for example:
  • http://www.scidev.net/content/news/eng/scientists-unravel-workings-of-ancient-malaria-drug.cfm
  • http://www.newscientist.com/article.ns?id=dn4079
  • http://pubs.acs.org/cen/coverstory/8151/8151sciencereview2.html
  • http://www.innovations-report.de/html/berichte/medizin_gesundheit/bericht-20672.html
  • See also Editorial in Nature .
  • This paper is cited as an Emerging Research Front (http://www.esi-topics.com/erf/2005/december05-SanjeevKrishna.html ) in the Science Citation Index for December 2005 (>100 citations in 2 years since publication).
  • Saadoun S, Papadopoulos MC, Krishna S. (2003). Water transport becomes uncoupled from K + siphoning in brain contusion, bacterial meningitis, and brain tumours: immunohistochemical case review. Journal of Clinical Pathology, 56 : 972-975.
  • Barrett M, Burchmore RJS, Stich A, Lazzari JO, Frasch C, Cazzulo JJ, Krishna S. (2003). The trypanosomiases. The Lancet , 362 :1469-1480.
  • Planche T, Agbenyega T, Bedu-Addo A, Ansong D, Owusu-Ofori A, Micah F, Anakwa C, Asafo-Agyei E, Hutson AD, Stacpoole P, Krishna S. (2003). Severe malaria in African children: prognosis and optimization of management. Clinical Infectious Diseases, 37 : 890-897.
  • Muhia DK, Swales CA, Eckstein-Ludwig U, Saran S, Polley SD, Kelly JM, Schaap P, Krishna S, Baker DA. (2003). Multiple splice variants encode a novel adenylyl cyclase of possible plastid origin expressed in the sexual stage of the malaria parasite Plasmodium falciparum . Journal of Biological Chemistry, 278 : 22014-22.
  • Invited reviews
  • Krishna S. (2003). Malaria. In “ Conn's Current Therapy ” (Eds. Rakel and Bope). Elsevier Science (USA). P105-113.
  • Joët T, Morin C, Fischbarg F, Louw AI, Eckstein-Ludwig U, Woodrow C, Krishna S. (2003). Validation of the Plasmodium falciparum hexose transporter as a novel therapeutic target. Expert Opinion on Therapeutic Targets, 7 :593-602.
  • Planche T, Dzeing A, Emmerson AC, Onanga M, Kremsner PG, Engel K, Kombila M, Ngou-Milama E, Krishna S. (2002). Plasma glutamine and glutamate concentrations in Gabonese children with Plasmodium falciparum infection. Quarterly Journal of Medicine, 95 : 89-97.
  • Saadoun S, Papadoupolos MC, Davies DC, Krishna S, Bell BA. (2002) Aquaporin-4 expression in human brain tumors. Journal of Neurology, Neurosurgery, and Psychiatry, 72 : 262-265.
  • Adjuik M, Agnamey P, Babiker A, Borrmann S, Brasseur P, Cobelens F, Diallo S, Faucher JF, Garner P, Gikunda S, Kremsner PG, Krishna S, Lell B, Loolpapit M, Matsiegui P-B, Missinou MA, Mwanza J, Ntoumi F, Olliaro P, Osimbo P, Rezbach P, Sisse M, Some E, Taylor WRJ (2002). Artesunate-amodiaquine versus amodiaquine for uncomplicated Plasmodium falciparum malaria in African children. Lancet, 359 : 1365-1372.
  • Manning SK, Woodrow C, Zuniga FA, Iserovich P, Fischbarg J, Louw AI, Krishna S. (2002). Mutational analysis of the hexose transporter of Plasmodium falciparum and development of a three-dimensional model. Journal of Biological Chemistry, 277 (34):30942-3094
  • Saadoun S, Papdopoulos MC, Davies CD, Bell BA, Krishna S . (2002). Increased aquaporin 1 water channel expression in human brain tumours. British Journal of Cancer, 87 : 621-623.
  • Nealon C, Dzeing A, Müller-Römer U, Planche T, Sinou V, Kombila M, Kremsner P, Parzy D, Krishna S. (2002). Intramuscular bioavailability and clinical efficacy of artesunate in Gabonese children with severe malaria. Antimicrobial Agents and Chemotherapy, 46 : 3933 - 3939.
  • Joët T, Holterman L, Stedman TT, Kocken C, van der Welt A-M, Thomas A, Krishna S (2002). Comparative characterizaton of hexose transporters of Plasmodium knowlesi, Plasmodium yoelii and Toxoplasma gondii highlights functional differences within the apicomplexan family Biochemical Journal, 368 (Pt 3):923-929.
  • Pukrittayakamee S, Krishna S, ter Kuile F, Wilaiwan O, Williamson DH, White NJ. (2002). Alanine metabolism in acute falciparum malaria. Tropical Medicine and International Health, 7 : 911-918.
  • Invited reviews
  • Papadopoulos MC, Krishna S, Verkman AS. (2002). Aquaporin water channels and brain edema. Mount Sinai Journal of Medicine, 69 : 242-248.
  • Stich A, Abel PM, Krishna S. (2002). Human African Trypanosomiasis. British Medical Journal, 325 : 203-206.
  • Krishna S, Eckstein-Ludwig U, Joët T, Uhlemann A-C, Morin C, Webb R, Woodrow C, Kün J, Kremsner PG. (2002). Transport processes in Plasmodium falciparum - infected erythrocytes: potential as new drug targets. International Journal of Parasitology, 32 :1567-1573.
  • Kremsner PG & Krishna S. Antimalarial cocktails – tropical flavours of the month. (2002) Lancet, 360 1998-1999.
  • Krishna S, Planche T, Agbenyega T, Woodrow C, Agranoff D, Bedu-Addo G, Owusu-Ofori A, Adabie Appiah J, Ramanathan S, Mansor S, Navaratnam V (2001). Bioavailability of intrarectal artesunate in Ghanaian children with moderate malaria. Antimicrobial Agents and Chemotherapy, 45 : 509-516.
  • Meade, J. C., Li, C., Stiles, J. K., Moate, M. E., Penny, J. I., Krishna, S., and Finley, R. W. (2001). The Trypanosoma cruzi genome contains ion motive ATPase genes which closely resemble Leishmania proton pumps. Parasitology International, 49 (4), 309-320.
  • Krishna S, Woodrow C, Webb R, Penny J, Takeyasu K, Kimura M, East MJ (2001). Expression and functional characterization of a Plasmodium falciparum Ca 2+ -ATPase (PfATP4) belonging to a subclass unique to apicomplexan organisms. Journal of Biological Chemistry, 276 , 10782-10787 .
  • Krishna S, Nagaraja NV, Planche T, Agbenyega T, Bedo-Addo G, Ansong D, Owusu-Ofori A, Shroads AL, Henderson G, Hutson A, Derendorf H, Stacpoole PW. (2001). Population pharmacokinetics of intramuscular quinine in children with severe malaria Antimicrobial Agents and Chemotherapy, 45 : 1803-1809.
  • Teerijoki H, Krasnov A, Gorodilov Y, Krishna S, Mölsä H. Rainbow trout glucose transporter (OnmyGLUT1): translation in Xenopus oocytes and expression in fish embryos. (2001) Journal of Experimental Biology, 204 (15): 2667-2673.
  • Papdopoulos MC, Saadoun S, Woodrow CJ, Davies CD, Costa-Martins P, Moss RF, Krishna S, Bell BA. Occludin expression in microvessels of neoplastic and non-neoplastic human brain (2001). Journal of Neuropathology and Applied Neurobiology, 27 : 384-395.
  • Rozmajzl P, Kimura M, Woodrow CJ, Krishna S, Meade JC. (2001). Characterisation of P-type ATPase 3 in Plasmodium falciparum . Molecular and Biochemical Parasitology, 116 : 117 - 126.
  • Warwick-Davis J, Watson AJ, Griffin GE, Krishna S, Shattock RJ. (2001). Enhancement of Mycobacterium tuberculosis -induced tumor necrosis factor alpha production by human monocytes by an activated T-cell membrane-mediated mechanism. Infection and Immunity, 69 : 6580-6587.
  • Planche T, Krishna S, Kombila M, Engel K, Faucher JF, Ngou-Milama E, Kremsner PG. (2001). A comparison of laboratory methods for the assessment of children with malaria American Journal of Tropical Medicine and Hygiene, 65 : 599-602.
  • Invited reviews
  • Whitty C, Krishna S. (2001) “ Side Effects of Drugs ”. Chapter 28. Elsevier. (Ed. J.K. Aronson).
  • Krishna S, Webb R, Woodrow CJ. (2001). Transport proteins of Plasmodium falciparum : defining the limits of metabolism. International Journal of Parasitology, 31 : 1331-1342.
  • Agbenyega T, Angus B, Bedu-Addo G, Baffoe-Bonnie B, Guyton T, Stacpoole P, Krishna S. Glucose and lactate kinetics in children with severe malaria. (2000). Journal of Clinical Endocrinology and Metabolism, 85 :1569-1576 .
  • Watt G, Kantopong P, de Souza M, Chanbanchaerd P, Jongsakul K, Ruangweerayud R, Loomis-Price L, Myint KS, Birx D, Polonis V, Brown AE, Krishna S. (2000). HIV-1 suppression during acute scrub typhus. Lancet, 356 : 475-479.
  • Bannister LH, Hopkins JM, Fowler RE, Krishna S, Mitchell GH. (2000) Ultrastructure of rhoptry development in Plasmodium falciparum erythrocytic schizonts. Parasitology, 121 (Pt 3), 273-87.
  • Woodrow CJ, Burchmore R, Krishna S. Hexose permeation pathways of Plasmodium falciparum -infected erythrocytes ( 2000). Proceedings of the National Academy of Sciences (USA), 97 (18), 9931-6.
  • Krishna S, Woodrow CJ, Burchmore RJS, Saliba K, Kirk K. (2000). Hexose transport in asexual stages of Plasmodium falciparum and kinetoplastidae. Parasitology Today, 16 (12), 516-21.
  • Bannister LH, Hopkins JM, Fowler RE, Krishna S, Mitchell GH (2000). A brief illustrated guide to the ultrastructure of Plasmodium falciparum asexual blood stages. Parasitology Today, 16 (10), 427-33.
  • Invited reviews
  • Woodrow C, Ribiero I, Krishna S. (2000) “ Side Effects of Drugs ”. Chapter 28, p304-313. Elsevier. (Ed. J.K. Aronson).
  • Krishna S, Woodrow C, Webb R, Takeyasu K, Kimura M. (2000). P-type ATPases of malaria parasites. Proceedings of an International Conference on Na/K pump and related pumps, 18 th -23 rd August, 1999 (ed. K. Taniguchi).
  • Jones R, Nealon C, Whitty C, Newman P, Krishna S (2000). Cerebral malaria complicated by acute liver failure. Clinical Intensive Care, 11 : 327-332.
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