Henry Staines

Research interests

Transmembrane solute transport in apicomplexan parasites

Research methods

Functional transport assays: radio-tracer, patch-clamp, fluorometric, haemolysis

Parasite culture

Heterologous protein expression

Biography

Following a B.Sc. in Biochemistry at the University of Kent at Canterbury, I studied for a D.Phil. in Cellular Physiology at the University Laboratory of Physiology, Oxford. During this time and my initial postdoctoral years, I examined the transport mechanisms used by the malaria parasite, Plasmodium falciparum, to obtain nutrients and export waste products while developing within human red blood cells. Having been awarded a Wellcome Trust Research Career Development Fellowship, I am now studying transport mechanisms in a wider range of unicellular parasites.

Key publications

H. M. Staines, S. Ashmore, H. Felgate, J. Moore, T. Powell and J. C. Ellory (2006). Solute transport via the new permeability pathways in Plasmodium falciparum-infected human red blood cells is not consistent with a simple single channel model. Blood, 108, 3187-3194

H. M. Staines, T. Powell, J. C. Ellory, S. Egée, F. Lapaix, G. Decherf, S. L. Y. Thomas, C. Duranton, F. Lang and S. M. Huber (2003). Modulation of whole-cell currents in Plasmodium falciparum-infected human red blood cells by holding potential and serum. J. Physiol., 552, 177-183

H. M. Staines, J. C. Ellory and K. Kirk (2001). Perturbation of the pump-leak balance for Na⁺ and K⁺ in malaria-infected erythrocytes. Am. J. Physiol., 280, C1576-C1587

Honours and awards

2005-2009 Wellcome Trust RCD Fellowship

1997 The Peter Beaconsfield Prize

1996 Inaugural Oxford/ANU Exchange Programme student

Collaborators and funders

Professor Kiaran Kirk ( Australian National University)

Professor Clive Ellory (University of Oxford)

Professor Trevor Powell (University of Oxford)

Dr Robert Wilkins (University of Oxford)

Dr Kelly Chibale (University of Capetown Medical School)

Contact details

Address: CMM-Centre for Infection, St George’s, University of London, Cranmer Terrace, Tooting, London SW17 0RE